Identification of Label-Retaining Cells in Mouse Endometrium
نویسندگان
چکیده
منابع مشابه
Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers.
BACKGROUND The endometrium, lining of the uterus, is a highly active organ that is remodelled periodically during the lifespan. Different studies suggest the presence of an adult or progenitor stem cell (PSC) population in this tissue because of its cyclic regenerative capacity. METHODS In this study, we aim at identifying and localizing the putative PSC population in the murine uterus using ...
متن کاملIn vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum.
Periosteum is known to contain cells that, after isolation and culture-expansion, display properties of mesenchymal stromal/stem cells (MSCs). However, the equivalent cells have not been identified in situ mainly due to the lack of specific markers. Postnatally, stem cells are slow-cycling, long-term nucleoside-label-retaining cells. This study aimed to identify and characterise label-retaining...
متن کاملLabel-retaining cells of the bladder: candidate urothelial stem cells.
Adult tissue stem cells replicate infrequently, retaining DNA nucleotide label (BrdU) for much longer periods than mature, dividing cells in which the label is diluted during a chase period. Those "label-retaining cells" (LRCs) have been identified as the tissue stem cells in skin, cornea, intestine, and prostate. However, in the urinary tract uroepithelial stem cells have not yet been identifi...
متن کاملRole of label-retaining cells in estrogen-induced endometrial regeneration.
Candidate stem/progenitor cells have been identified in mouse endometrium as label-retaining cells (LRCs). The role of endometrial stem/progenitor cells in initiating estrogen-stimulated endometrial growth in prepubertal and cycling mice was investigated following a single 17β-estradiol (E2) injection in bromodeoxyuridine (BrdU)-labeled and -chased (LRC), ovariectomised mice. Proliferating (Brd...
متن کاملKinetics of Label Retaining Cells in the Developing Rat Kidneys
BACKGROUND The kidney is a specialized low-regenerative organ with several different types of cellular lineages. The BrdU label-retaining cell (LRCs) approach has been used as part of a strategy to identify tissue-specific stem cells in the kidney; however, because the complementary base pairing in double-stranded DNA blocks the access of the anti-BrdU antibody to BrdU subunits, the stem cell m...
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ژورنال
عنوان ژورنال: STEM CELLS
سال: 2006
ISSN: 1066-5099
DOI: 10.1634/stemcells.2005-0411